Paediatric populationThe pharmacokinetics in infants and children with infection at doses of 10, 20 and 40 mg/kg showed Cmax values approximating to those in adults following 500, 1000 and 2000 mg doses, respectively. Probenecid competes with meropenem for active tubular secretion and thus inhibits the renal excretion of meropenem with the effect of increasing the elimination half-life and plasma concentration of meropenem. The other ingredient is sodium carbonate. Your doctor will decide on the dose that you need. Pharmacokinetic studies performed in patients have not shown significant pharmacokinetic differences versus healthy subjects with equivalent renal function. Similar to other beta-lactam antibacterial agents, the time that meropenem concentrations exceed the MIC (T>MIC) has been shown to best correlate with efficacy. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Meropenem is licensed for children over 3 months of age. Meropenem will be given to you as an injection or infusion into a large vein. It works by killing the bacteria that cause these problems. The measured renal clearance and the effect of probenecid show that meropenem undergoes both filtration and tubular secretion. Alternatively, doses up to 1 g can be given as an intravenous bolus injection over approximately 5 minutes. The following table of pathogens listed is derived from clinical experience and therapeutic guidelines. Hence given the high cost of clinical trials and R&D these branded drugs tend to be priced heavily for the firms to recover the money spent and also to earn windfall profits ( Patent life is only for 20 years for these drugs ). The reason so explaining above its not possible due to following explanation as said above The main difference by which you can distinguish is the price for eg, the difference between the brand-name drug and the generic could be Rs 10 (Rs 35 and Rs 25 respectively), depending on what the retailer keeps in each case, the actual difference in the price paid by a customer of a brand-name drug and that of a generic could be, perhaps, only Rs 4 (Rs 27 and Rs 23). Talk to your doctor if you need 9 or more vials daily for a prolonged period, especially if you have been advised to follow a low salt (sodium) diet. Buy Meropenem 500 MG Injection Online. In particular, tell your doctor or nurse if you are taking any of the following medicines: Oral anti-coagulant agent (used to treat or prevent blood clots). Find dosages, compare prices and get up to 20% off on prescription medicines. The maximum daily dose of this product is equivalent to ≥27% of the WHO recommended maximum daily intake for sodium. The most commonly reported meropenem-related laboratory adverse events were thrombocytosis (1.6 %) and increased hepatic enzymes (1.5-4.3 %). Meropenem may also be used for purposes not listed in this medication guide. However, bacteria may exhibit resistance to more than one class of antibacterials agents when the mechanism involved include impermeability and/or an efflux pump(s). After infusion over 5 minutes Cmax values are 52 and 112 μg/ml after 500 and 1000 mg doses respectively. If not used immediately in-use storage times and conditions are the responsibility of the user. However, it will not treat a viral infection. Additional Information: Meropenem has been associated with headache; tingling or pricking skin (paraesthesia). The sole metabolite of meropenem had a similar profile of toxicity in animal studies. There are limited safety data available to support the administration of a 2 g dose in adults as an intravenous bolus injection. This medicinal product contains 90 mg sodium per dose, equivalent to 4.5% of the WHO recommended maximum daily intake of 2 g sodium for an adult. Meropenem injection is used to treat skin and abdominal (stomach area) infections caused by bacteria and meningitis (infection of the membranes that surround the brain and spinal cord) in adults and children 3 months of age and older. 4.7 Effects on ability to drive and use machines. For the full list of excipients, see section 6.1. EUCAST clinical MIC breakpoints for meropenem (2015-01-01, v5), Haemophilus influenzae1,2 and Moraxella catarrhalis2, Gram-positive anaerobes except Clostridium difficile. Meropenem Injection IP 1g Mero 1g full explain with this medicine...?? This should be particularly taken into account for those on a low salt diet. Date HS Code Description Destination Port of Loading Unit Quantity Value (INR) Per Unit (INR) Nov 17 2016: 30049099: MERO INJ 1 G, MEROPENEM INJECTION IP 1G: Maldives Non species related breakpoints are based on the following dosages: EUCAST breakpoints apply to meropenem 1000 mg x 3 daily administered intravenously over 30 minutes as the lowest dose. This should be particularly taken into account for those on a low salt diet. Meropenem may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection. If you are allergic to meropenem or any of the other ingredients of this medicine (listed in section 6). Broncho-pulmonary infections in cystic fibrosis, Complicated skin and soft tissue infections, Management of febrile neutropenic patients, Severe pneumonia including hospital and ventilator-associated pneumonia, eosinophilia, thrombocytopenia, leucopenia, neutropenia, agranulocytosis, haemolytic anaemia, angioedema, anaphylaxis (see sections 4.3 and 4.4), diarrhoea, vomiting, nausea, abdominal pain, antibiotic-associated colitis (see section 4.4). You should check with your doctor if you are not, Your injection should not be mixed with or added to solutions that contain other, The injection may take about 5 minutes or between 15 and 30 minutes. Product after reconstitution is clear colourless to yellow solution. 3 Susceptibility of staphylococci to carbapenems is inferred from the cefoxitin susceptibility. Some people may develop side effects like nausea, vomiting, diarrhea, rash or local redness and swelling at the site of injection. Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp resistance. The hospital staff make it up into a solution before injection. The identification and antimicrobial susceptibility tests on any such isolate must be repeated and if the result is confirmed the isolate sent to a reference laboratory. These include reduced numbers of platelets (which may make you bruise more easily), increased numbers of some white blood cells, decreased numbers of other white cells and increased amounts of a substance called ‘bilirubin’. 6.6 Special precautions for disposal and other handling. 6 The beta-lactam susceptibility of streptococcus groups A, B, C and G is inferred from the penicillin susceptibility. Wholesaler of Meropenem Injections - Merotrol Injection, Meroza IV Injection, Humog-150 HP Injection and Merolan Injection offered by Patel Medisales ( A Unit Of Rajshree Medicals ), Bengaluru, Karnataka. Swelling, redness, pain, or soreness at the injection site may occur. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes (see section 6.2, 6.3 and 6.6). 4.2 Posology and method of administration. 24*7 network in all area of gujarat. Alternatively, meropenem doses of up to 20 mg/kg may be given ... Injection Meropenem to be used for bolus intravenous injection should be constituted with sterile water for injection. As with all beta-lactam antibiotics, serious and occasionally fatal hypersensitivity reactions have been reported (see sections 4.3 and 4.8). Meropenem & Sulbactam For Injection IP 1g is used in the treatment of severe bacterial infections. MERO PALM. However, the protein binding is so low that no interactions with other compounds would be expected on the basis of this mechanism. If a severe allergic reaction occurs, the medicinal product should be discontinued and appropriate measures taken. Changes in blood tests, including tests that show how well your kidneys are working. The medicinal product is supplied in pack sizes of 1 or 10 vials. Buy low price Meropenem Injection Ip 1G in Sadashiv Peth, Pune. This information is intended for use by health professionals, Meropenem 1 g powder for solution for injection or infusion. Antibiotic Injection We are a leading Manufacturer of meropenem injection ip, 2.25 g piperacillin tazobactam injection, 1g meropenem injection ip, piperacillin tazobactam injection usp, 4.5 gm piperacillin tazobactam injection and cefoperazone sulbactam injection from Mumbai, India. Simultaneous administration of antibiotics with warfarin may augment its anti-coagulant effects. The potential effect of meropenem on the protein binding of other medicinal products or metabolism has not been studied. for injection or infusion. 3 Susceptibility of staphylococci to carbapenems is inferred from the cefoxitin susceptibility. Standard aseptic techniques should be used for solution preparation and administration. Acute bacterial infection of the brain (meningitis). No dose adjustment is necessary in patients with hepatic impairment (see section 4.4). A solution for bolus injection is prepared by dissolving the drug product meropenem in sterile water for injection to a final concentration of 50 mg/ml. The risk may vary with the underlying infection, age and general status of the patient so that the contribution of the antibiotic to the increase in INR (international normalized ratio) is difficult to assess. c) Each Tablet […], Cetirizine Hydrochloride & Ambroxol Hydrochloride Tablets IP 5mg/60mg Taj Pharma, Is generic medicine as safe as branded drugs? A population model developed from data in 79 patients with intra-abdominal infection or pneumonia, showed a dependence of the central volume on weight and the clearance on creatinine clearance and age. If you accidentally use more than your prescribed dose, contact your doctor or nearest hospital straight away. 1349.56 mg powder in a 40ml Type-I, tubular, clear glass vial with stopper (bromobutyl rubber with aluminum seals having white colour polypropylene discs). When multiple doses are administered 8-hourly to subjects with normal renal function, accumulation of meropenem does not occur. Glanders and melioidosis: Use of meropenem in humans is based on in vitro B.mallei and. It is preferable to avoid the use of meropenem during pregnancy. Consideration should be given to official guidance on the appropriate use of antibacterial agents. There was no evidence of increased sensitivity to meropenem in juveniles compared to adult animals. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes (see sections 6.2, 6.3, and 6.6). When multiple doses are administered 8-hourly to subjects with normal renal function, accumulation of meropenem does not occur. Instructions for doing this are provided in this leaflet (in the section called ‘Instructions for giving Meropenem to yourself or someone else at home’). BiotransformationMeropenem is metabolised by hydrolysis of the beta-lactam ring generating a microbiologically inactive metabolite. There are limited safety data available to support the administration of a 40 mg/kg dose in children as an intravenous bolus injection. Meropenem is generally well tolerated by the central nervous system. There was no evidence of mutagenic potential in a conventional test battery and no evidence of reproductive toxicity including teratogenic potential in studies in rats up to 750 mg/kg and in monkeys up to 360 mg/kg. Powder for solution for injection or infusion. Continue typing to refine. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. To email a medicine you must sign up and log in. Prescribers are advised to take into account the local prevalence of resistance in these bacteria to penems. Meropenem Injection Ip 1G offered by TAPADIYA OVERSEAS is available with multiple payment options and easy delivery. varies across the European Union. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Generic drugs are, therefore, cheaper. The company’s products include prescription solutions, lifesaving drugs, anti-cancer drugs, veterinary products, consumer brands, and CNS drugs. 3 hours when stored at controlled room temperature (15-25°C); 8 hours when stored under refrigerated conditions (2-8°C); Do not freeze the reconstituted. Pharmacotherapeutic group: Antibacterials for systemic use, carbapenems. Staphylococcus aureus (methicillin-susceptible)£, Staphylococcus species (methicillin-susceptible) including Staphylococcus epidermidis, Streptococcus milleri group (S. anginosus, S. constellatus, and S. intermedius), Peptostreptococcus species (including P. micros, P anaerobius, P. magnus), Species for which acquired resistance may be a problem, $ Species that show natural intermediate susceptibility, £ All methicillin-resistant staphylococci are resistant to meropenem. Information about drug Meropenem includes cost of the drug and the type of drug - tablet, capsule, syrup, cream, gel, ointment, liquid or injection. transaminases increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased. penicillins or cephalosporins). The maximum daily dose of this product is equivalent to ≥27% of the WHO recommended maximum daily intake for sodium. Other changes in your blood. Intravenous powder for solution: 500 mg/vial and 1 gram/vial. Your doctor or nurse will normally give Meropenem to, However, some patients, parents and carers are trained to give Meropenem at home. A positive direct or indirect Coombs test may develop during treatment with meropenem. In a review of 4,872 patients with 5,026 meropenem treatment exposures, meropenem-related adverse reactions most frequently reported were diarrhoea (2.3 %), rash (1.4 %), nausea/vomiting (1.4 %) and injection site inflammation (1.1 %). What Meropenem looks like and contents of the pack. The generic drug has the same “active ingredient” as the brand-name drug. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes (see sections 6.2, 6.3, and 6.6). Do not throw away any medicines via waste water or house hold waste. Intravenous bolus injection administration. Not to be sold by retail without the prescription of Registered Medical Practitioner. transaminases increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased. Additional considerations for dosing are needed when treating patients with renal insufficiency (see further below). It … Meropenia™ 1000: Meropenem Injection IP 1000mg, Each vial contains: Meropenem IP (Sterile) equivalent to anhydrous Meropenem 1000mg, sodium carbonate IP(Sterile) equivalent to Sodium (as buffer) 90.2mg. A study of 12 patients administered meropenem 1000 mg 8 hourly post-surgically for intra-abdominal infections showed a comparable Cmax and half-life to normal subjects but a greater volume of distribution 27 l. The average plasma protein binding of meropenem was approximately 2 % and was independent of concentration. A study in patients with alcoholic cirrhosis shows no effect of liver disease on the pharmacokinetics of meropenem after repeated doses. Any of these side effects could affect your ability to drive or operate machines. Due to the rapid onset and the extent of the decrease, co-administration of valproic acid/sodium valproate/valpromide with carbapenem agents is not considered to be manageable and therefore should be avoided (see section 4.4). The pharmacokinetics of meropenem in neonates requiring anti-infective treatment showed greater clearance in neonates with higher chronological or gestational age with an overall average half-life of 2.9 hours. Consideration should be given to official guidance on the appropriate use of antibacterial agents. 1349.56 mg powder in a 40ml Type-I, tubular, clear glass vial with stopper (bromobutyl rubber with aluminum seals having white colour polypropylene discs). MEROPENEM RANBAXY vials contain either 500mg or 1g of meropenem (as meropenem trihydrate) as the active ingredient. — = Susceptibility testing not recommended as the species is a poor target for therapy with the drug. 24*7 network in all area of gujarat. Taj Pharma India Limited manufactures and distributes medicines. However, if it is almost time for your next injection, skip the missed injection. Pantoprazole for Injection 40 mg. PANTHERA IV. The mean meropenem clearance values were 5.8 ml/min/kg (6-12 years), 6.2 ml/min/kg (2- 5 years), 5.3 ml/min/kg (6-23 months) and 4.3 ml/min/kg (2-5 months). Always use Meropenem exactly as your doctor has told you. 5 Non-species related breakpoints have been determined mainly from PK/PD data and are independent of the MIC distributions of specific species. Meropenem Injection IP 1g (Merokem) Taj Pharma. It works by killing bacteria, which can cause serious infections. Interaction studies have only been performed in adults. Lots of people don’t know the difference between generic and branded medicines and that’s where doctor’s and pharmacies take the advantage and prescribe only branded medicines to earn more commission. Dose adjustment of Merokem 1 gm Injection may be needed. Seizures have infrequently been reported during treatment with carbapenems, including meropenem (see section 4.8). If you miss an injection, you should have it as soon as possible. Meropenem is considered high in sodium. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable. 250 mg . The medicinal product does not require any special storage condition. Use in patients with liver disease: patients with pre-existing liver disorders should have liver function monitored during treatment with meropenem. Meropenem Injection IP 1g. or very severe infections. Meronem i.v. Medicinal products that inhibit peristalsis should not be given. Merokem 1 gm Injection is probably safe to use during breastfeeding. Meropenem is generally well tolerated by the central nervous system. Meropenem + Sulbactam is a combination of two medicines: Meropenem and Sulbactam. Alternatively, meropenem doses of up to 20 mg/kg may be given as an intravenous bolus over approximately 5 minutes. Meropenem is licensed for children over 3 months of age. Patients who have a history of hypersensitivity to carbapenems, penicillins or other beta-lactam antibiotics may also be hypersensitive to meropenem. Meropenem 500mg powder for solution for injection or infusion Meropenem 1g powder for solution for injection or infusion meropenem Read all of this leaflet carefully before you start taking this medicine. 2-8°C) should be used within 1 hour after it has left the refrigerator. Interaction studies have only been performed in adults. It is recommended that the INR should be monitored frequently during and shortly after coadministration of antibiotics with an oral anti-coagulant agent. To develop these block buster drugs they take a minimum of 10 years. Limited post-marketing experience indicates that if adverse reactions occur following overdose, they are consistent with the adverse reaction profile described in section 4.8, are generally mild in severity and resolve on withdrawal or dose reduction. In a review of 4,872 patients with 5,026 meropenem treatment exposures, meropenem-related adverse reactions most frequently reported were diarrhoea (2.3 %), rash (1.4 %), nausea/vomiting (1.4 %) and injection site inflammation (1.1 %). The medicinal product does not require any special storage condition. Only clear colourless to yellow solution, free from particles should be used. Infection affecting the lungs (pneumonia). within 30 minutes following reconstitution. The potential effect of meropenem on the protein binding of other medicinal products or metabolism has not been studied. The recommended dose regimens are shown in the table below: Severe pneumonia including hospital and ventilator-associated pneumonia. Meropenem 1000mg Allopathic Merowin 1g Injection, For Anti Infective & Common Disease Medicines, Intramuscular Rs 1,000/ Vial Get Latest Price Packaging Size : SINGLE VIAL PACKING The intravenous formulation was well tolerated in animal studies. Each ml of reconstituted solution contains 50 mg Meropenem. This includes any possible side effects not listed in this leaflet. Infections of the mouth or the vagina that are caused by a fungus (thrush). The required dose should be administered after completion of the haemodialysis cycle. They are for use only for organisms that do not have specific breakpoints. All generic drugs get approved only when their bio-equivalence is proved and not prior to that. At first generic medicines have the same amount of dosage as compared to branded medicines and the amount of content is also the same, the difference is only in size shape and taste. Do not drive or use machines if you experience this side effect. A study of 12 patients administered meropenem 1000 mg 8 hourly post-surgically for intra-abdominal infections showed a comparable Cmax and half-life to normal subjects but a greater volume of distribution 27 l. The average plasma protein binding of meropenem was approximately 2 % and was independent of concentration. Meropenem is cleared by haemodialysis with clearance during haemodialysis being approximately 4 times higher than in anuric patients. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. The dose of meropenem administered and the duration of treatment should take into account the type of infection to be treated, including its severity, and the clinical response. If you are not sure if any of the above applies to you, talk to your doctor or nurse before using Meropenem. If you miss a dose of Merokem 1 gm Injection, please consult your doctor. The most important part is that India is the manufacturing hub of generic medicines and India alone accounts for 90% of the total exports all over the world. Decreases in blood levels of valproic acid have been reported when it is co-administered with carbapenem agents resulting in a 60-100 % decrease in valproic acid levels in about two days. eosinophilia, thrombocytopenia, leucopenia, neutropenia, agranulocytosis, haemolytic anaemia, angioedema, anaphylaxis (see sections 4.3 and 4.4), diarrhoea, vomiting, nausea, abdominal pain, antibiotic-associated colitis (see section 4.4). Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome), blood creatinine increased, blood urea increased, General disorders and administration site conditions, Thrombophlebitis, pain at the injection site, Injection site reactions (pain, swelling, redness). Meropenem is used to treat the following in adults and children aged 3 months and older: Infection affecting the lungs (pneumonia), Lung and bronchial infections in patients suffering from cystic fibrosis, Complicated urinary tract infections, Complicated infections in the abdomen, Infections that you can catch during or after the delivery, Complicated skin and soft tissues infections, Acute bacterial infection of the brain (meningitis). See section 4. There is no dose adjustment necessary (see section 4.2). Pharmacokinetic/Pharmacodynamic (PK/PD) relationship. no meningitis). Meropenem may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection. Meropenem injection is in a class of medications called antibiotics. The prevalence of acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp resistance. Broncho-pulmonary infections in cystic fibrosis, Complicated skin and soft tissue infections, Management of febrile neutropenic patients. Alternatively, doses up to 1 g can be given as an intravenous bolus injection over approximately 5 minutes. Infections that you can catch during or after the. Kindly do not self administer. Do not freeze the reconstituted solution. Severe pneumonia, including hospital and ventilator-associated pneumonia. If you get any side effects, talk to your doctor or nurse. When suggestions are available use up and down arrows to review and ENTER to select. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. A White to pale yellow crystalline powder. There have been many reports of increases in the anti-coagulant effects of orally administered anti-coagulant agents, including warfarin in patients who are concomitantly receiving antibacterial agents. This target has not been established clinically. Haemodialysis will remove meropenem and its metabolite. DBL Meropenem for Injection contains 208 mg sodium carbonate anhydrous for each gram of meropenem (anhydrous potency). 1g . Intravenous bolus injection administration. 1 Meropenem breakpoints for Streptococcus pneumoniae and Haemophilus influenzae in meningitis are 0.25 mg/l (Susceptible) and 1 mg/l (Resistant). It allows continued monitoring of the benefit/risk balance of the medicinal product. A dose is usually given every 8 hours. There are no established dose recommendations for patients receiving peritoneal dialysis. There are limited data to support the administration of these dose adjustments for a unit dose of 2 g. (based on “unit” dose range of 500 mg or 1 g or 2 g, see table above). Before starting treatment with this medicine, you should tell your doctor if you have epilepsy, liver or kidney problems or if you are allergic to any antibiotic. Product after reconstitution is clear colourless to yellow solution.

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