E. coli is an infection found worldwide. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. Merrem IV. In the Merrem IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. Probenecid may increase levels of Merrem IV by reducing its elimination through the kidneys. View Meropenem’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg.com. 6 Several studies have indicated that the most important factor governing the neurotoxicity of a carbapenem is the concentration achieved in the brain tissue. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Digestive Disorders: Common Misconceptions. hemoperitoneum (0.2%). Local adverse events that were reported with Merrem IV were as follows: Systemic adverse events that were reported with Merrem IV occurring in greater than 1.0% of the patients were. Co-administration of probenecid with meropenem is not recommended. In the MERREM IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. Merrem IV is effective against susceptible strains of E. coli, H. influenzae, K. pneumoniae, N. meningitidis, P. aeruginosa, and many other bacteria. failure, kidney failure, seizure and shock reported with Merrem IV, increased in What drugs interact with Merrem IV (meropenem injection)? Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Background: Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. … Merrem IV prevents bacteria from forming the walls that surround them. Antibiotics treat E. coli infection. There are many types of E. coli (Escherichia coli). What to … Pneumonia may be contagious for 2-14 days. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; nausea; redness, pain, or swelling at the injection site; burning or tingling in the hands or feet; confusion; Some side effects can be serious. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). MERREM IV. Symptoms may vary depending on the strain the individual contracts. If any of these effects last or get worse, tell your doctor or pharmacist promptly. It is unknown if Merrem IV enters breast milk. Merrem IV. Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. Tell your doctor or nurse right away if you or your child have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine. Complicated Skin and Skin Structure Infections The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with Symptoms include severe abdominal pain and bloody diarrhea. decreasing the serum concentrations of valproic acid. If it affects one lung, it is termed single pneumonia. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. It’s good at treating severe and complicated bacterial infections. For patients with varying degrees of renal impairment, the incidence of heart failure, kidney failure, seizure and shock reported with MERREM IV, increased in patients with moderately severe renal impairment (creatinine clearance 10 to 26 mL/min) [see DOSAGE AND ADMINISTRATION,WARNINGS AND PRECAUTIONS, Use In Specific Populations and In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with Merrem IV. Merrem IV is necessary, then supplemental anti-convulsant therapy should be The following are discussed in greater detail in other sections of labeling: Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Should I Get the Pneumonia Vaccine Every Year? Consult your doctor before breastfeeding. Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. Terms of Use. A second infection may happen. and animal studies suggest that carbapenems may inhibit the hydrolysis of Visit the FDA MedWatch website or call 1-800-FDA-1088. Usually, the goal of medications given for pneumonia is to limit the spread of the disease. In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. This is not a complete list of side effects and others may occur. Increased levels of Merrem IV in the body could increase side effects like nausea, vomiting, and headache. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Side Effects for MERREM IV (meropenem injection) are also known as adverse reactions. MERREM IV was studied in 200 neonates and infants less than 3 months of age. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. A Skin Rash 2. Meropenem Side Effects Swelling, redness, pain, or soreness at the injection site may occur. Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. Serious adverse effects are rare. (1.3%), shock (1.2%), and pruritus (1.2%). Pneumonia is inflammation of the lung usually caused by bacterial or viral infection (rarely, also by fungi) that causes the air sacs to fill with pus. In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. These may be encountered; Pain at the site of injection. Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. See additional information. Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. It should be used during pregnancy only if clearly needed. Pediatric Patients with Serious Bacterial Infections (excluding Bacterial Meningitis): Merrem IV was studied in 515 pediatric patients (3 months to less than 13 years of age) with serious bacterial infections (excluding meningitis, see next section) at dosages of 10 mg/kg to 20 mg/kg every 8 hours. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. Abdominal pain. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies. Constipation 3. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. What are the possible side effects of meropenem? Increased levels of meropenem in the body could increase side effects like nausea, vomiting, and headache. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Adverse Reactions. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. Risk of Breakthrough Seizures Due to Drug Interaction with Valproic Acid. mL/min). Symptoms and signs of E. coli infection include diarrhea, stomach cramps, and sometimes fever.
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